Antipsychotics and Diabetes

Training Of Nurses

Nurses have been trained to care for the residents of the mental hospitals since the late   19th century.  Historically, the pharmacologic treatment of the disruptive and psychotic   behaviors has been managed using the conventional anti-psychotic agents.  Hence, even during   the therapeutic disease, such agents can form side effect that are often troublesome.  It is   especially true for the elderly population, which shows enhanced susceptibility to the delirium,   sedation, syndrome, tardive, dyskinesis, and anti-cholinergic effects. Observational and case  reports indicates that the probability of the association between the atypical and conventional   anti-psychotics, and diabetes mellitus onset. The new-diabetes onset as well as existing disease exacerbation in individuals treated with anti-psychotics either without or with the family history, and developmental risk factors of diabetes. Such cases were unusual in diabetes development which occurred shortly after beginning the treatment from anti-psychotics. All these symptoms tend to disappear as soon as the treatment of anti-psychotic is discontinued.

In Other Cases

In various other cases, the condition of diabetes does not resolve completely. Various other medications such as anti-hyperglycemia are reduced highly on anti psychotic agent’s discontinuation. In few instances, the redevelopment of diabetes and its evidence indicates the regimen of anti psychotics has been restarted. These kinds of cases involve atypical anti psychotic with numerous dosing regimens and variety of strength. For many years, in the nursing home, potential misuse of the 8 psychotropic drugs in the treatment of the behavioral and psychosis disturbances has been a huge issue.  The psychotropic medication employed in the nursing homes has been substantially altered. Generally, a reduction has been observed in the anti psychotic use and there is an elevation in the antidepressant usage.  The current reported rates of the drugs of psychotic’s usage shows striking interstate variation and inter-facility. The anti-psychotic medication was employed widely in schizophrenia treatments and in numerous other psychosis forms. This drug falls into two categories: 1) typical & 2) atypical anti-psychotics.

One of the most atypical expected includes haloperidol which possess higher affinity of the D2 or type 2 dopamine-like receptors as it tends to cause extra-pyramidal side effects. The second generation and atypical anti-psychotics medications such as olanzapine, quetiapine, and clopazine are considered to be therapeutically targeted because of their lower extra-pyramidal side incidences because of their lower D2 receptor incidences. However, the main side effects of the second generation anti-psychotics include the symptom development which is often similar to the condition of Type 2 diabetes. It occurs due to peripheral insulin resistance following gain in weight observed in the individuals who are prescribed these drugs.